In this project we are interested in the conformational heterogeneity of the CypA protein as captured from crystallography and spectroscopic methods at various temperatures. These methods allow for the experimental determination of multiple states, and the molecular simulations on Folding@home will allow us to develop a better understanding of this conformational heterogeniety. This project aims to reach key insights about the heterogeneity of proteins and the significant role this plays in their activation.
List of Contributors
This project is managed by Dr. Sonya Hanson at Memorial Sloan Kettering Cancer Center.
Sonya Hanson is a postdoctoral fellow at the Memorial Sloan Kettering Cancer Center studying the origin of selectivity of target small molecule kinase inhibitors for the treatment of various cancers.
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