In this project, we take a look at Aurora Kinase A, a mitotic kinase involved in regulating the maturation of centrosomes as well as the formation of the mitotic spindle. Interestingly, these two cellular pools of kinase are regulated by two orthogonal mechanisms. This project aims to provide atomistic detail to a set of biophysical experiments being performed by our collaborators in the Levinson Lab as we seek to understand the role of phosphorylation and an allosteric activator known as TPX2. This project will help provide insight into the structural dynamics of the kinase, potentially identifying a route to selectively inhibit specific pools of the kinase. of particular note, Aurora Kinase A and its regulatory phosphatase are frequently mutated in melanoma, leading to hyperactivation of the TPX2-bound kinase due to phosphorylation.
11432: Aurora A kinase domain (~60000 atoms, 20 snapshots/WU)
Gerstner Sloan Kettering graduate student Steven Albanese is the lead scientist behind this project.
List of Contributors
This project is managed by Steven Albanese at Memorial Sloan Kettering Cancer Center.
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