Projects 13110-13127,13141-13150

Cause: unspecified

The mechanisms by which the human mind grows and learns are highly complex and not well understood. Prior studies have shown that a protein known as the NMDA receptor, which sits at the synapses of neurons, is critical to such processes. When this receptor is fully activated, neurons begin to remodel and change. With such a critical role, it is not surprising that it has also been implicated as playing a role in numerous neurological disorders, from depression to schizophrenia to alzheimer's disease and many others. However, currently we only have a very general idea of how the receptor changes as it goes from inactivated to activated. Even more interesting, there are numerous molecules that are known to modulate this receptor, and bind to it in many different locations, but the details of how they work are not well characterized. This project will endeavor to study the behavior of this protein and, later on, how certain molecules affect it. This project is being done in conjunction with Dr. Anton Sinitskiy of the Pande lab, as well as collaborators at Genentech, Inc.

List of Contributors

This project is managed by Dr. Nathaniel Stanley at Stanford University & Genentech, Inc.

Nathaniel is interested in using molecular simulations and other computational tools to improve our understanding of biology. He is currenlty part of the Pande laboratory at Stanford University. He received his PhD from Universitat Pompeu Fabra in Barcelona, Spain, where he worked on the project under Prof. Gianni De Fabritiis. He studied disordered and membrane proteins during his time there, and intends to continue similar work here at F@H.

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