This project simulates several myosins found in the human body. Myosins are the proteins responsible for most of the force generated by the body, from the contraction of muscles to the movement of materials around the cell. Although superficially similar, myosins actually differ substantially in their properties and distribution in the body. This project is studying those differences, especially the differences in speed and power. We are especially interested in how this might help us understand diseases that result from defects in myosin, including Usher syndrome and, especially, hypertrophic and dilated cardiomyopathies. Myosin was featured as the PDB Molecule of the Month in June 2001.
List of Contributors
This project is managed by Justin R. Porter at Washington University in St. Louis.
Justin is an MD/PhD student at Washington University School of Medicine in St. Louis in Greg Bowman's lab.
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