Disease Type: Alzheimer's
Butyrylcholinesterase (BChE) is a key enzyme that catalyzes the hydrolysis of the neurotransmitter acetylcholine and shows an increased activity in patients suffering from Alzheimer’s disease (AD), making this enzyme a primary target in treating AD. These projects explore the strength, mechanism, and dynamics of BChE inhibition by a series of synthetic organic molecules (dialkyl- and cholinyl-phenyl phosphate derivatives) that have been synthesized, or may be synthesized in the future, and biochemically tested by our experimental colleagues, with whom we recently published our first collaborative effort "Synthesis, biochemical evaluation, and molecular modeling studies of aryl and arylalkyl di-n-butyl phosphates, effective butyrylcholinesterase inhibitors" (Bioorganic & Medicinal Chemistry 25, 2017, 3171-3181).
This project is managed by Prof. Eric J. Sorin at California State University, Long Beach.
Dr. Sorin joined the Pande Lab in 2000 to begin his graduate studies. In 2007 he accepted a faculty position at California State University, Long Beach, where he teaches General Chemistry, Physical Chemistry, Chemical Communications, and several other courses. The Sorin Lab, which houses two Folding@Home servers dedicated primarily to studying RNA folding and the interaction of potential drug molecules with the butyrylcholinesterase enzyme, is composed predominantly of volunteer undergraduate research students, with a Master's student thrown in from time to time for good luck ;o)
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