Disease Type: Unspecified
These projects simulates the folding of several mutants of WW domain, a 35-residue beta-sheet protein that folds on the microsecond timescale. We are trying to understand how mutations change the folding landscape, and how we can use Markov State Model aproaches to better predict the effects of mutations.
This project is managed by Prof. Vincent Voelz at Temple University.
Dr. Voelz's research focuses on using new simulation methods to unravel the mysteries of how proteins self-assemble into their functional folds, and to design folding and binding properties of proteins and peptide mimetics from first principles. The Voelz Lab participates in the Folding@home project, hosting two servers at Temple University. Dr. Voelz was formerly a postdoctoral scholar in the Vijay Pande lab at Stanford University.
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