Projects 8670-8682

Cause: unspecified

These projects simulate the folding of several mutants of the Villin headpiece, a three-helix protein that folds on the microsecond time scale. We are trying to understand how mutations change the folding landscape, and how we can use Markov State Models and surprisal approaches to better identify mutation-induced conformations.

List of Contributors

This project is managed by Prof. Vincent Voelz at Temple University.

Dr. Voelz's research focuses on using new simulation methods to unravel the mysteries of how proteins self-assemble into their functional folds, and to design folding and binding properties of proteins and peptide mimetics from first principles. The Voelz Lab participates in the Folding@home project, hosting two servers at Temple University. Dr. Voelz was formerly a postdoctoral scholar in the Vijay Pande lab at Stanford University.

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