Projects 9411-9420,9430,9431

Cause: cancer

Tumor suppressor protein p53 regulates the cell cycle in response to a variety of molecular signals throughout an organism's development. Mutations of p53 are often associated with disease, most notably cancers, and can completely corrupt the process of apoptosis, or programmed cell death. This study seeks to elucidate the folding mechanism of the disordered C-termini of p53, with the hope of understanding how mutations in this region may affect folding and subsequently proliferate uncontrolled cellular growth.


List of Contributors

This project is managed by Carlos Xavier Hernández at Stanford University.

URL: http://www.cxhernandez.com

Carlos Xavier Hernández is a Biophysics graduate student in the Pande group. He is interested in the molecular evolution of proteins, how it affects their structure and function, and possible therapeutic applications.

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