Projects 9838-9842

Cause: unspecified

Go big by going… small! We want to study really large proteins and protein complexes, maybe as large as ribosomes or ion channels in neurons. One possible way to reach this goal is to run computations for each part of a big complex separately, and then assemble the resulting models together. We think we know how to do so, but first we need to test our approach on simpler systems.

Insulin is a small protein used by the pancreas to signal to the whole organism whether to consume more glucose or not. Disruptions in the processes of secreting and sensing insulin lead to various diseases, including diabetes mellitus, metabolic syndrome and polycystic ovary syndrome. Insulin can form dimers (complexes consisting of two insulin molecules), hexamers (complexes of six insulin molecules) and even larger aggregates resembling those formed under Alzheimer’s, but only the monomer is physiologically active. In this project, we want to run simulations of insulin monomers and dimers and see whether our methodology for studying big systems works here.

Previous projects 9810-9836 were about a monomer, and this project is about a dimer.


List of Contributors

This project is managed by Dr. Anton Sinitskiy at Stanford.

Anton Sinitskiy is a postdoc in the Pande group at Stanford University. He works on the computational investigation of large biomolecular complexes.

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