In these projects, we are simulating the dynamics of ubiquitin to study the effect of various mutations on the structural landscape of ubiquitin.
Ubiquitins are small proteins that regulate the activity and processing of other proteins. Ubiquitins attach themselves to other target proteins and 'label' them; this process is called ubiquitination. Ubiquitination is involved in various biological processes such as cell death, gene repair, immunity and many more. In most cases, ubiquitination leads to degradation of the target protein. In many cases, ubiquitination also changes the location, activity and quantity of the target proteins in the cell.
List of Contributors
This project is managed by Neha Vithani at Washington University in St. Louis.
Neha is a postdoc at Washington University School of Medicine in St. Louis in Greg Bowman's lab.
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